TC Duoc Lieu, 10:128-132, 2005
The Effect of Morinda citrifolia Fruit Extracts of Viet Nam on Rat Hepatic Enzyme Metabolism
Do Thi Tuyen; Ly Thi Bich Thuy; Nguyen Thi Ngoc Dao,
Morinda citrifolia, known commercially as noni, grows widely throughout the Pacific and is one of the valuable sources of traditional medicines among Pacific island societies. The authors tested the effect of noni fruit extracts of Viet Nam on rat hepatic enzyme metabolism. Noni extracts markedly reduced the pathologic changes observed in CC14-chronically treated rats. It significantly increased the superoxide dismutase (SOD) enzyme activity by 31% compared with control model rats, and 38% compared with the untreated controls. The imbalance in lipid metabolism could be the reason for increase in lipid peroxidation. The treatment with noni significantly inhibited the rise of MDA, and improved antioxidant status in CCI4-treated rats. Furthermore, noni fruit extracts significantly increased the P450 activity in comparison with the negative control (especially, P450 reductase NADPH (CPR) activity).