2005 IFT Annual Meeting, July 15-20 – New Orleans, Louisiana. Session 18E, Nutraceutical & Functional Foods: General I
Morinda citrifolia L. (Noni): A dual inhibitor of COX-2/5-LOX Enzymes
Palu, A.K., Jensen, C.J., Zhou, B-N., Su, C.
Morinda citrifolia L.(Noni) fruit juice has been used in all of Polynesia for over 2000 years for treatment of diseases such as cancer, diabetes, hypertension, gout and many other ailments that had been reported in the literature. However, only recently that Noni has been proven scientifically to be efficacious in many of the diseases listed above and much more. Scientists around the world including us are using different types of experiments (in-vitro & in-vivo) to test the antimicro-bial, anticancer, antihypertensive and anti-inflammatory effects of Noni. The anti-inflammatory effects of Noni and the Brand TAHITIAN NONI(R) Juice (TNJ) was discovered by Chen Su et al (Wang et al, 2002) from our lab in which they demonstrated that Tahitian Noni fruit juice and TNJ are inhibitors of COX-2 enzymes. The previous discovery has led to the investigation and the subsequent discovery that Tahitian Noni fruit juice and TNJ also affect the lipoxygenase enzymes which are also part of the arachi-donic acid metabolic pathways. Tahitian Noni fruit juice and TNJ are potent inhibitors of 5-LOX and 15-LOX enzymes. Hence, Tahitian Noni fruit juice and TNJ are dual inhibi-tors of both COX-2 and 5-LOX enzymes which are potential candidate for neuroprotection, anticancer and anti-inflammation. These inhibitory effects on the arachidonic acid metabolic pathways might explain at least in part why Tahitian Noni fruit juice and TNJ are used as dietary supplements to improve our health naturally. (view original abstract online at http://ift.confex.com/ift/2005/techprogram/paper_30120.htm).