Subchronic toxicity, immunoregulation and anti-breast tumor effect of Nordamnacantal, an anthraquinone extracted from the stems of Morinda citrifolia L.

BMC Complement Altern Med. 2018 Jan 27;18(1):31.
Subchronic toxicity, immunoregulation and anti-breast tumor effect of Nordamnacantal, an anthraquinone extracted from the stems of Morinda citrifolia L.
Abu N, Zamberi NR, Yeap SK, Nordin N, Mohamad NE, Romli MF, Rasol NE, Subramani T, Ismail NH, Alitheen NB.

Nordamnacanthal, reportedly found in noni fruit, was cytotoxic to breast cancer cells in vitro. It was not toxic to mice when ingested for 28 days. But nordamnacanthal did delay the development of tumors in mice that had been injected with cancer cells. (original abstract available at https://www.ncbi.nlm.nih.gov/pubmed/29374471).