Cytotechnology. 2016 Oct;68(5):1999-2013.
Cell cycle arrest and mechanism of apoptosis induction in H400 oral cancer cells in response to Damnacanthal and Nordamnacanthal isolated from Morinda citrifolia.
Shaghayegh G, Alabsi AM, Ali-Saeed R, Ali AM, Vincent-Chong VK, Zain RB.
Damnacanthal and nordamnacanthal, isolated from noni roots, were cytotoxic to oral squamous cell carcinoma (oral cancer) cultures in vitro. This cytotoxicity involved internucleosomal cleavage of DNA, activation of intrinsic apoptosis pathway, and cell cycle arrest. These findings suggest that damnacanthal and nordamnacanthal may be potentially used as antitumor agents. (original abstract available at https://www.ncbi.nlm.nih.gov/pubmed/27488882).