Effect of iridoid (containing plants) on AGE formation and degradation.

Glycative Stress Research 2016 Volume 3 Issue 2 Pages 56-64.
Effect of iridoid (containing plants) on AGE formation and degradation.
Abe Y, Yagi M, Uwaya A, Isami F, Yonei Y.

The anti-AGE activity of noni, cornelian cherry, and olive extracts were tested with three model proteins (human serum albumin, collagen and keratin). The AGE degrading activity of these was measured by their ability to break the α-diketone structure of 1-phenyl-1, 2-propanedione (PPD).  All extracts displayed anti-AGE activity, but noni seed extract had the highest activity. All extracts displayed potential AGE breaking ability. The results demonstrate that these plants may prevent AGE formation, as well as degrade existing AGEs. (available online at https://www.jstage.jst.go.jp/article/gsr/3/2/3_056/_article/-char/en).