Noni contains competitive ligand(s) binding to GABAa agonist receptors as an anxiolytic.

The 232nd American Chemical Society National Meeting, San Francisco, CA. September 10-14, 2006.
Noni contains competitive ligand(s) binding to GABAa agonist receptors as an anxiolytic.
Shixin Deng, Afa K Palu, Bing-Nan Zhou, Jarakae C. Jensen, Brett J West. AGFD 67.

For the first time, the biological mechanism of noni fruit’s effect to help relieve stress and anxiety (anxiolytic), calm and relax, improve mood and sense of well being is reported. Noni fruit extracts effectively bind to gamma-aminobutyric acid A (GABAa) receptors. These are inhibitory neurotransmitter receptors found in the brain. Such binding activity is well known to produce sedative and anxiolytic effects. (view original abstract at http://oasys2.confex.com/acs/232nm/techprogram/P995203.HTM)