Journal of Cosmetics, Dermatological Sciences and Applications.  2012, 2, 74-78.
Noni seed oil topical safety, efficacy, and potential mechanisms of action. 
Palu AK, West BJ, Jensen CJ.

Noni seed oil did not cause any skin reactions in a repeat insult patch test with 49 adult volunteers. Noni seed oil was non-comedogenic in a four-week clinical trial involving 23 adolescent volunteers.  The oil also exhibited in-vitro anti-inflammatory activity in COX-2 and 5-LOX enzyme inhibition assays. The results demonstrate that noni seed oil is safe for topical use and is non-comedogenic. (original abstract available at